Sampson-Ayers is the partnership of Jeff Sampson and Sara Ayers, two renowned vocalists/composers. Their music focuses primarily (and sometimes entirely) on the human voice.

Sara Ayers creates unflinchingly intimate soundscapes using her voice sampled, layered, looped and pitch-shifted combined with occasional guitar washes and a warm bedrock of molten noise. Her richly textured sonic atmospheres vary in tone from the surreal whispers of angels to wall-of-sound banshee wails...a soundtrack for forgotten dreams. Rhythm and News characterized her sound as "shimmering sonic poetry," and The Kettle Black described it as "a must-have for fans of angelic voices."

Jeff Sampson, whether solo or in collaboration, specializes in improvisation, live performance and live recording. Eclectic Earwig Music noted that "he can hum, croon, moan, chant like a Tibetan monk, chant like a Western monk, or sing high counter-tenor," and Wind and Wire characterized his sound as evoking "grey skies, bare trees and lonely spaces."